RNA Details
Disease Name
cardiomegaly
Tissue
heart
RNA Symbol
mir-1
RNA ID
RNA Type
miRNA
Alteration Pattern
down regulation
Species
rattus norvegicus
Detection Methods
immunofluorescence; PCR etc.
Target
FBLN2
Pathway
MAPK SIGNALING PATHWAY
PubMed ID
Title
Therapeutic Cardiac-Targeted Delivery of miR-1 Reverses Pressure Overload-Induced Cardiac Hypertrophy and Attenuates Pathological Remodeling
Year
2013
Function
"Targeted overexpression of miR-1 has a potential therapeutic effect in the treatment of cardiac hypertrophy and the prevention of poor cardiac remodeling, while miR-1 replacement therapy can reduce the incidence of myocardial fibrosis."